Written by James L. Wilson, DC, ND, PhD. Republished with permission from AdrenalFatigue.org

Are your patients confused about salt? Worried because the media and medicine appear to unanimously suggest that each shake of a salt shaker drives a nail into the coffin? Do they crave salt or feel better when adding it to their food? If so, they are not alone. Lots of people are wondering the same things, especially the many experiencing adrenal fatigue. I hope this blog will help ease your concerns and provide more useful guidance on salt use.

Salt in the Media

Much of recent research and media coverage has focused on lowering salt intake and the harmful effects of sodium over-consumption. There has even been talk of requiring warning labels on foods containing over a certain amount of sodium. However, there is an alternate point of view based on scientific research that has been generally ignored by the media and traditional medicine. From this perspective, there can be health benefits to salting foods (within moderation) if patients crave salt or notice they feel better when adding salt to food[i] [ii]. So which position is correct? The answer is both.

The Research

An article in the August 14, 2014 issue of the New England Journal of Medicine spoke on the relationship of salt consumption and cardiovascular deaths. It reported that Americans consume about 3.5 grams of sodium daily (approximately 1½ teaspoons), slightly lower than the average global intake of 3.95 grams per day (approximately 2 teaspoons)[iii]. The article concluded that the global incidence of both hypertension and cardiovascular deaths increased once sodium consumption surpassed 2.0 grams per day.

They then theorized that a worldwide 2.3 grams/day reduction in individual sodium consumption to less than 2.0 grams/day would result in approximately 1.65 million fewer deaths annually from cardiovascular events. The authors’ rationale is that for every 2.3 grams/day reduction in sodium consumption, systolic blood pressure drops an average of 3.82 mm Hg[iv], and for every 3.82 mm Hg drop in systolic blood pressure, approximately 1.65 million lives would be saved due to the established relationship between lowering blood pressure and decreasing deaths from cardiovascular causes.

This is an impressive statistical meta-analysis-type study and worth consideration. However, keep in mind it is a theoretical rather than clinical model and the number of lives saved were only predicted, not actualized.

The study also did not take into account a number of other variables associated with hypertension, sodium consumption and cardiovascular disease, and it assumed a causal relationship of salt to cardiovascular-related deaths based primarily on only correlational evidence. It is important to keep in mind that there has never been a long-term study showing the direct relationship between sodium consumption and cardiovascular deaths[v]. The evidence has only been associative, not causal.

Studies evaluating the association between sodium intake and cardiovascular problems have been inconsistent. A number of recent studies have reported an association between low sodium intake and an increased risk of cardiovascular death[vi] [vii] [viii]. Even the recommendations for maximum daily sodium intake vary among different health organizations and groups: 2.0 grams by the World Health Organization (WHO)[ix], 2.3 grams by the United States Center for Disease Control and Prevention (CDC)[x], 1.5-2.4 grams by other studies and experts[xi] [xii] [xiii] [xiv] [xv], and 1.2- 2.4 grams by some major institutions[xvi]. In fact, the global effects of sodium consumption and the heterogeneity of these effects according to age, sex, and country have not been clearly established[xviii].

The PURE Study

In contrast, results from the Prospective Urban Rule Epidemiology (PURE) study–involving over 156,000 people aged 35 to 70 from different socioeconomic backgrounds in 17 countries–showed the importance of considering potassium along with sodium intake, and that low potassium intake as well as high sodium intake may be dangerous to health.

They found a strong interaction between sodium excretion, potassium excretion and hypertension; increased blood pressure was more strongly associated with high sodium excretion in people with lower potassium excretion. To achieve greater health benefits, including blood-pressure reduction, the authors suggested higher quality diets rich in potassium (more fruits and vegetables) rather than aggressive sodium reduction alone[xx] [xxi].

Some of the authors of the PURE study also used somewhat different modeling techniques. They separated subjects by sodium consumption into groups of high (>7 grams/day), medium (3-6 grams/day) and low (<3 grams/day) sodium intake. Their statistical results revealed that those who consumed more than 7 grams of sodium per day had a higher number of cardiovascular and other-cause deaths than those who consumed 3-7 grams of sodium daily. But those who consumed less than 3.0 grams of sodium/day had a higher death rate than those in the medium consumption group (3-6 grams/day).

When the death rate of the group consuming more than 7 grams per day was compared with the group consuming less than 3 grams per day, the group consuming less than 3 gm per day had a higher death rate in all categories, including increased risk of death from cardiovascular causes, stroke, myocardial infarct and heart failure, as well as the composite of all those previously mentioned. In addition, all-causes mortality (dying from any cause) was also more common among those in the low salt intake group[xxii].

In commenting on the results of the PURE study, Suzanne Oparil, editor of the New England Journal of Medicine, said, “… This large study does provide evidence that both high and low levels of sodium excretion may be associated with an increased risk of death and cardiovascular-disease outcomes, and that increasing the urinary potassium excretion counterbalances the adverse effect of high sodium excretion.

These provocative findings beg for randomized controlled outcomes to compare reduced sodium intake with the usual diet. In the absence of such a trial, the results argue against reduction of dietary sodium as an isolated public health recommendation.”[xxiii] In other words, the jury is still out on whether sodium restriction should become an accepted universal recommendation as a preventive measure for cardiovascular disease.

As can be seen from the research above, there are conflicting conclusions about the health benefits of significantly lowering sodium consumption. If Americans consuming approximately 3.4 grams/day of sodium take the advice of the first study and cut their sodium intake by 2.3 grams/day, they would reduce their daily intake to 1.1 grams/day.

As some of the studies referenced above show, such a low daily sodium intake places people in the highest risk group for developing cardiovascular disease and dying of any of several cardiovascular-related causes in addition to all-cause mortality, rather than preventing it. It also ignores the tremendous influence stress and other factors play in hypertension[xxiv] [xxv], including tissue levels of nutrients such as potassium[xxvi], magnesium[xxvii] [xxviii] and niacin[xxix].

What About Salt Cravings & Adrenal Fatigue?

What about the people who crave salt or have adrenal fatigue? In the 1940s and earlier, physicians advised patients with low adrenal function to increase their salt intake to help with their fatigue, which was in part due to their lack of ability to retain sodium. Aldosterone, a mineralocorticoid steroid hormone produced by the adrenal glands, plays a primary role in sodium retention. I have found that patients with adrenal fatigue often find it very beneficial to add salt to their food and sometimes to their drinking water.

Water follows sodium in the body, so when mineralocorticoid levels (such as aldosterone) are low, sodium is excreted along with water resulting in salt cravings and thirst to replenish sodium and water depletion. In severe cases, I have recommended adrenal fatigue patients keep a glass of salted water (salted to taste) by their bedsides to drink first thing in the morning before rising. Doing this appears to greatly improve their ability to function in the morning.

Cortisol, another major adrenal steroid hormone, is a glucocorticoid but also acts as a mineralocorticoid. Therefore, when cortisol is low, even if aldosterone is normal, there may be insufficient sodium retention and excess potassium accumulation in the body. This creates a need for more sodium to replenish the sodium loss, rebalance the sodium/potassium ratio, and carry on sodium’s many functions. Sodium is one of the most prominent circulating cations aiding pH balance and substituting in for divalent cations, such as magnesium or calcium, when either is in short supply. When sodium is low, the natural physiological response is a salt craving to replace the lost sodium.

In adrenal fatigue, high blood pressure is not a usual concern. In fact, it is common for adrenal fatigue patients to have low blood pressure or blood pressure that stays flat or drops by 10 mmHg or more when they rise from a prone position. This is due to the mild hypovolemia and hyponatremia created by the low cortisol, and possibly low aldosterone seen in adrenal fatigue. As mentioned above, patients often find it very beneficial to salt their food and sometimes their drinking water to taste.

Conclusion

As long as popular opinion and research funding focus primarily on a single causal agent for such a wide-spread and complex problem as cardiovascular disease, there will continue to be lots of research dollars spent chasing a myth while the American public continues living their stressful lives—a greater cause of hypertension than sodium consumption[xxxi].

If patients are eating a well-balanced, healthy diet without processed food, their desire for or lack of desire for salt will probably guide them sufficiently well in sodium consumption. Listen to your intuition and follow it when it comes to adding or not adding salt. What does their body tell them?

However, If your patients are sensitive to salt, as are about 6% of the population, or have existing hypertension and they notice that their blood pressure rises when they take in extra sodium from food, they need to be very conscious about salt intake and monitor it judiciously.

If they are consuming the North American average of about 3.4 grams/day of sodium, then they are generally in safe waters.

If your patients have adrenal fatigue and the typically low blood pressure that goes along with this syndrome, their sodium intake is likely insufficient, especially if they have salt cravings. Tell them to salt their foods to taste and see if it makes them feel better. If it does, continue doing it until it does not help anymore.

Adrenal fatigue responds well to lifestyle modifications that reduce stress and improve stress management when they are combined with dietary changes and supplements designed to help strengthen the adrenal glands, nutritionally support adrenal hormone production and balance the hypothalamus-pituitary-adrenal (HPA) axis stress response system. Once adrenal hormone production has been optimized by these measures, your patients will probably notice a decreased desire for salt. As this changes, continue to be guided by your taste.

Using this common sense approach, most worries about too much or too little salt consumption can be relegated to salting to taste, leaving the finer points to academic discussions and spirited talk among colleagues – allowing you and your patients to enjoy food and life more completely.
Original blogs can be found at Adrenalfatigue.org, here.

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Dr James Wilson

James L. Wilson, DC, ND, PhD, received his PhD in Human Nutrition from the University of Arizona, with minors in Immunology, Microbiology, Pharmacology and Toxicology, and research in Cellular Immunology. His doctorates in Chiropractic Medicine and Naturopathic Medicine are from the Canadian Memorial Chiropractic College and the Ontario College of Naturopathic Medicine (CCNM).

As one of the 14 founding members of CCNM, now the largest Naturopathic College in the world, Dr. Wilson has long been on the forefront of alternative medicine. For over twenty-five years, he was in private practice in Canada and the United States. In 1998, Dr. Wilson coined the term ‘adrenal fatigue’ to identify below optimal adrenal function resulting from stress and distinguish it from Addison’s disease.

With a researcher’s grasp of science and a clinician’s understanding of its human impact, Dr. Wilson has helped many physicians understand the physiology behind and treatment of various health conditions. He is acknowledged as an expert on alternative medicine, especially in the area of stress and adrenal function. Dr. Wilson is a respected and sought after lecturer and consultant in the medical and alternative healthcare communities in the United States and abroad.

References:

[i] David Brownstein, Salt Your Way to Health, 2nd ed. (West Bloomfield, MI: Medical Alternatives Press, 2010), 145 pp.

[ii] James L. Wilson, Adrenal Fatigue: The 21st Century Stress Syndrome, 26th ed. (Petaluma, CA Smart Publications, 2014), 361 pp.

[iii] Dariush Mozaffarian et al., “Global Sodium Consumption and Death from Cardiovascular Causes,” The New England Journal of Medicine 371, no. 7 (2014): 624-633.

[iv] World Health Organization (WHO), Prevention of Cardiovascular Disease: Guidelines for Assessment and Management of Cardiovascular Risk (Geneva: World Health Organization (WHO), 2007).

[v] Suzanne Oparil, “Low Sodium Intake — Cardiovascular Health Benefit or Risk?,” The New England Journal of Medicine 371, no. 7 (2014).

[vi] M.J. O’Donnell et al., “Salt Intake and Cardiovascular Disease: Why Are the Data Inconsistent?,” 34, no. 14 (2013): 1034-1040.

[vii] Oparil, “Low Sodium Intake — Cardiovascular Health Benefit or Risk?.”

[viii] Niels A. Graudal, Thorbjørn Hubeck-Graudal, and Gesche Jürgens, “Effects of Low-Sodium Diet Vs. High-Sodium Diet on Blood Pressure, Renin, Aldosterone, Catecholamines, Cholesterol, and Triglyceride (Cochrane Review),” American Journal of Hypertension 25, no. 1 (2012): 1-15.

[ix] World Health Organization (WHO), Guideline: Sodium Intake for Adults and Children (Geneva: World Health Organization (WHO), 2012).

[x] Centers for Disease Control and Prevention (CDC), “Americans Consume Too Much Sodium (Salt),” (2011). http://www.cdc.gov/features/dssodium/ (accessed 12/01/2014).

[xi] Paul K. Whelton et al., “Sodium, Blood Pressure, and Cardiovascular Disease: Further Evidence Supporting the American Heart Association Sodium Reduction Recommendations,” Circulation 126, no. 24 (2012): 2880-2889.

[xii] National Institute for Health and Clinical Excellence, “Prevention of Cardiovascular Disease at Population Level (Nice Public Health Guidance 25),” (2010). https://www.nice.org.uk/guidance/ph25.

[xiii] Dietary Guidelines Advisory Committee, Report of the Dietary Guidelines Advisory Committee on the Dietary Guidelines for Americans, 2010, to the Secretary of Agriculture and the Secretary of Health and Human Services2011.

[xiv] U.S. Department of Agriculture and U.S. Department of Health and Human Services, 2010 Report of the Dietary Guidelines Advisory Committee on the Dietary Guidelines for Americans2010.

[xv] Scientific Advisory Committee on Nutrition, Salt and Health2003.

[xvi] Mozaffarian et al., “Global Sodium Consumption and Death from Cardiovascular Causes.”

[xvii] Martin O’Donnell et al., “Urinary Sodium and Potassium Excretion, Mortality, and Cardiovascular Events,” The New England Journal of Medicine 371, no. 7 (2014): 612-623.

[xviii] Mozaffarian et al., “Global Sodium Consumption and Death from Cardiovascular Causes.”

[xix] Andrew Mente et al., “Association of Urinary Sodium and Potassium Excretion with Blood Pressure,” The New England Journal of Medicine 371, no. 7 (2014).

[xx] Ibid.

[xxi] O’Donnell et al., “Urinary Sodium and Potassium Excretion, Mortality, and Cardiovascular Events.”

[xxii] O’Donnell et al., “Urinary Sodium and Potassium Excretion, Mortality, and Cardiovascular Events.”

[xxiii] Oparil, “Low Sodium Intake — Cardiovascular Health Benefit or Risk?.”

[xxiv] S. Kulkarni et al., “Stress and Hypertension,” Wmj 97, no. 11 (1998): 34-38.

[xxv] Suzanne Oparil, Amin Zaman, and David A. Calhoun, “Pathogenesis of Hypertension,” Annals of Internal Medicine 139, no. 9 (2003): 761-776.

[xxvi] Maria Carolina M. D. Delgado, “Potassium in Hypertension,” Current Hypertension Reports 6, no. 1 (2004): 31-35.

[xxvii] Bruno Sontia and Rhian M. Touyz, “Role of Magnesium in Hypertension,” Archives of Biochemistry and Biophysics 458, no. 1 (2007): 33-39.

[xxviii] Fangzi Liao, Aaron R. Folsom, and Frederick L. Brancati, “Is Low Magnesium Concentration a Risk Factor for Coronary Heart Disease? The Atherosclerosis Risk in Communities (Aric) Study,” American Heart Journal 136, no. 3 (1998): 480-490.

[xxix] Harold E. Bays et al., “Blood Pressure-Lowering Effects of Extended-Release Niacin Alone and Extended-Release Niacin/Laropiprant Combination: A Post Hoc Analysis of a 24-Week, Placebo-Controlled Trial in Dyslipidemic Patients,” Clinical Therapeutics 31, no. 1 (2009): 115-122.

[xxx] The Merck Manual of Therapeutics and Materia Medica : A Source of Ready Reference for the Physician, ed. Merck and Co (Rahway, N.J.: Merck, 1940), 32-33.

[xxxi] K. G. Walton et al., “Stress Reduction and Preventing Hypertension: Preliminary Support for a Psychoneuroendocrine Mechanism,” J Altern Complement Med 1, no. 3 (1995): 263-283: 263.

[xxxii] Mozaffarian et al., “Global Sodium Consumption and Death from Cardiovascular Causes.”